The lymphatic circulation is also a key player in disease processes such as cancer metastasis ... FGF-2 stimulates both lymphangiogenesis and angiogenesis. FGF-2 upregulates VEGF-C expression ...

VEGF-D knockdown in 468 LN cells resulted in a marked ... tumor-associated lymphangiogenesis and angiogenesis and spontaneous metastasis to the lymph nodes and the lungs in this tumor model ...

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis ...

The functional lymphatic vessels transport inflammatory lymph-carrying inflammatory cells, catabolic factors and cytokines to the draining LNs and promote lymphangiogenesis, leading to an ...