The role of TBL1XR1 in lymphangiogenesis and lymphatic metastasis was examined by tube formation, cell invasion and wound-healing assays in vitro, and by a popliteal lymph node metastasis model in ...

The lymphatic circulation is also a key player in disease processes such as cancer metastasis ... FGF-2 stimulates both lymphangiogenesis and angiogenesis. FGF-2 upregulates VEGF-C expression ...

When a tumor develops, it creates a structure around itself called the tumor stroma, within which blood and lymphatic vessels ensure nutritional and respiratory biological exchanges. Lymphangiogenesis ...

The functional lymphatic vessels transport inflammatory lymph-carrying inflammatory cells, catabolic factors and cytokines to the draining LNs and promote lymphangiogenesis, leading to an ...

In this review, we summarize TAM ontogeny and polarization, and then explore how TAMs enhance tumor cell migration through the TME, thus facilitating metastasis. We also discuss how chemotherapy and ...

Lymphangiogenesis, i.e. the development of lymphatic vessels, is generally associated with a poor prognosis, as it favours the spread of metastases to other organs. By studying the cells that make ...

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion, intravasation, circulation, arrest/adhesion and extravasation require specific mechanical properties to allow ...

Using PET imaging, researchers analyzed 161 women and found that high amygdala activity (AmygA) was associated with lymph node (LN) metastasis in postmenopausal patients but not in premenopausal ...

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22904, United States Carter Immunology Center and University of Virginia Cancer Center, University of Virginia ...

Her expertise includes sensation-preserving mastectomy, hidden scar breast surgery, and oncoplastic breast surgery. A metastatic breast cancer diagnosis can be overwhelming. After receiving this ...