Acute and chronic liver injury models were performed in wild type and Trem-2-/-mice. Primary liver cells from both genotypes of mice were isolated for in vitro experiments. Results TREM-2 was ...

Scientists at EMBL and DKFZ have discovered how cells in the liver maintain their identity and avoid becoming tumour cells ...

Direct effects of BMP-9 on hepatic stellate cells (HSCs) and hepatocytes were studied in vitro, and the role of BMP-9 was examined in acute and chronic liver injury models in mice. Results Quiescent ...

Asterisks denote statistical significance. ns, no significant, * P < 0.05, *** P < 0.001, **** P < 0.0001. Inhibitor of ER stress 4-PBA effectively rescued the fasting-induced liver injury and ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, ...

Briefly, ACLF was induced in mice using carbon tetrachloride and primary hepatocytes were isolated and ... in ACLF in the context of MSC-based therapies and highlights CXCL8 as a potential target for ...

Repair of liver injury is initiated by interactions between injured hepatocytes and liver sinusoidal endothelial cells (LSEC), however, chronic injury can lead to fibrosis. Here, using a ...

A new study reveals that even low-dose, chronic exposure to air pollution can trigger liver inflammation, fibrosis, and metabolic disruptions, increasing the risk of fatty liver disease and other ...

Gene editing is already being used to treat a handful of rare genetic diseases; however, most therapies involve breaking or ...

and bone marrow of female mice while promoting stool excretion of PP-IX. Plasma biomarkers of liver injury, such as alanine aminotransferase (ALT) and alkaline phosphatase (ALP), were also reduced ...