In contrast, TLRs 3, 7, 8, and 9 are situated in the membranes of endosomes and lysosomes; the extracellular domain of the receptor and its ligand-binding site project into the interior of these ...

The predicted membrane topology showed a long extracellular N terminal that presumably constitutes the ligand binding site. Homology with the Ca 2+ receptor CaSR of the parathyroid, with ...

Death receptor 3 (DR3) is the only signaling receptor for TNF superfamily ligand TL1A, the dysregulation of which has been implicated in multiple inflammatory diseases such as inflammatory bowel ...

Can-Fite BioPharma (CANF) announced that its lead drug candidate Namodenoson was granted a patent for its use as an anti-obesity drug by the US ...

Researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug ...

Chemistry, 2010, 53, 1357. “Benzimidazole derivatives as novel serotonin 5-HT 6 receptor antagonists. A computacional and mutagenesis study of ligand-receptor interaction”. Drugs of the Future 2009, ...