Our work has generated investment ideas in health care, consumer electronics, finance technologies, transportation, AI-based Oppenheimer raised the firm’s price target on Ligand (LGND ...

Upon binding to a ligand – which can range from small molecules like cyclic AMP to peptides and large proteins – GPCRs undergo a conformational change that activates heterotrimeric G proteins ...

Here, the authors use a group II intron scaffold to achieve high-resolution RNA structures, visualize ligand-induced changes, and enable de novo modeling of non-coding RNAs. Here, the authors ...

The Japanese pharma had one asset rejected by the FDA and withdrew a regulatory application for another, but already this ...

First approved in 2010, RANK ligand (RANKL) inhibitor Prolia remains an important drug for Amgen. The company recorded sales of $3.25 billion for the drug last year, two thirds from the US market.

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

The two patients received the treatment as part of a UChicago Medicine pilot study focusing on the use of Eledon's anti CD40 ligand (CD40L) antibody tegoprubart (formerly AT-1501) as an ...