In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteome ...

While autophagy is relevant to many biological processes and often serves as a gatekeeper of homeostasis, when something goes wrong it can either lead to disease or be activated to fight against it.

Plants mobilize the endomembrane system for restoring homeostasis when stimulated by stresses. Though the function of ufmylation in ER stress and autophagy has been described in mammals, their ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

The generation of PI3P facilitates the recruitment of autophagy-related machinery, including the ATG16L1-ATG5-ATG12 complex, ATG3, and ATG7. These components work synergistically to conjugate ATG8 ...

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China ...

The roles of key proteins such as the microtubule-associated protein 1 light chain 3 (LC3), beclin 1, and p62 in autophagy initiation and substrate recognition were also explored. Further ...

The defect in autophagy by the depletion of axonal mitochondria is one of the main claims in the paper. The authors should work more on describing their results of LC3-II/LC3-I ratio, as there are ...

One of the key characteristics of Bluetooth LE Audio is the new high performing standards-based LC3 audio codec. LE Audio requires the LC3 codec which supports scaling from 345kbps to just 16kbps ...