The human AML cell lines MOLM-14, MonoMac-6, MV4-11, U937, HL60, and K562 cells were provided by the Translational Laboratory Shared Service, University of Maryland, Baltimore. Ba/F3 WT and FLT3-ITD ...

Four tumor cell lines: two human leukemia cell lines (erythroleukemia cell line K562, and acute promyelocytic leukemia cell line HL60), and two human solid tumor cell lines (lung carcinoma cell line ...

C-terminal amidation is a PTM that involves the addition of an amid group to the C-terminus of a peptide or protein. Currently there is no direct evidence to suggest that C-terminal amidation of ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

We used ovarian cancer cell lines, PA-1 and SKOV-3, with different p53 status (wild- and null-type, respectively). PEITC caused increased ROS-accumulation and inhibited proliferation selectively in ...

Run a brief analysis at the single-cell level, let’s use the common Seurat pipeline. set.seed(12345) sc <- CreateSeuratObject(counts = sc.counts, project = proj.name, meta.data = sc.meta) sc ## An ...

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

You're paying less per line each month than you would with a single line of the best cell phone plan overall. And that helps keep your monthly wireless bill manageable. There's something else to ...

Feb. 10, 2025 — Evolution is traditionally associated with a process of increasing complexity and gaining new genes. However, the explosion of the genomic era shows that gene loss and ...