Mutations of the isocitrate dehydrogenase (IDH) 1 and 2 genes occur in ~80% of lower-grade (WHO grade II and grade III) gliomas. Mutant IDH produces (R)-2-hydroxyglutarate, which induces DNA ...

2024 年美国FDA 批准上市新药50 个，其中小分子药物31 个，生物制品19 个。根据FDA 批准的新药说明书以及相关数据库和专利检索情况，文章简要介绍了 ...