If you’ve been diagnosed with or are at risk for high cholesterol (meaning you have too much of this waxy substance in your blood), your doctor may recommend a low-cholesterol diet. Learn what a ...

Currently, ionizable lipid nanoparticles (LNPs) represent the most advanced non-viral system for delivering nucleic acids. LNPs are composed of ionizable lipids, such as SM-102 in Moderna's vaccine ...

Introducing BEND Lipids One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids — key components of LNPs that change their charge to help them ...

LNPs typically consist of four fundamental components: ionizable lipids, polyethylene glycol (PEG)-lipids, phospholipids, and sterols (as shown in Figure 1A,B). This formulation has been successfully ...

Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Inserm, U1293, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, 46 Allée d’Italie, 69364 Lyon, France Centre ...

Eating more fruits and vegetables is an important part of a cholesterol-lowering diet, but grains can also play a role. For example, whole-wheat bread is a good option if you have high cholesterol.

Zocor (simvastatin) and Lipitor (atorvastatin) are both statin drugs, which are medications used to lower cholesterol levels in the blood. Statins primarily work by inhibiting the enzyme HMG-CoA ...

Well, for one thing, your cholesterol levels could reach such stratospheric levels that lipids start oozing from your blood vessels, forming yellowish nodules on your skin. That was the disturbing ...

Cationic charges in siRNA carriers can be provided by various materials, most typically polymers, lipids and inorganic nanomaterials. Inflammatory toxicity: lipoplexes are captured by Kupffer ...

Jan. 21, 2025 – Bernadette McLaughlin is 66 years old, walks 10 miles most days, eats mainly vegetables and tofu, and her standard cholesterol panel looks generally healthy. But there was one ...

This lipid core provides a hydrophobic environment ideal for encapsulating genetic materials such as messenger RNA (mRNA) or small interfering RNA (siRNA). LNPs typically contain ionizable lipids, ...