The three-signal paradigm tries to capture how the innate immune system instructs adaptive immune responses in three well-defined actions: (1) presentation of antigenic peptides in the context of MHC ...

The interleukin (IL)-20 is a subfamily part of the IL-10 family of cytokines that helps the liver respond to damage and disease ... far in terms of therapeutic possibilities of the IL-20 subfamily of ...

Objective The Interleukin-1 (IL-1) family plays an important regulatory role in the development of tumors, but its function is still unclear in head and neck squamous cell carcinoma (HNSCC). Analyzing ...

Opioid use during pregnancy—whether of highly addictive drugs like fentanyl or controlled opioids like buprenorphine—doubles ...

Among the cytokines produced by T cells, interleukin (IL ... with IL-17A and not with IL-1 or TNFα alone. These findings suggest a positive feedback loop, involving T cell activation by an ...

Through cytokine screening, we identified that interleukin-1β (IL-1β), a key mediator of inflammation, inhibits syncytia formation mediated by various SARS-CoV-2 strains. Mechanistically, IL-1β ...

Summary: Tocilizumab is a novel monoclonal antibody that competitively inhibits the binding of interleukin-6 (IL-6) to its receptor (IL-6R). Inhibiting the entire receptor complex prevents IL-6 ...

4 Tissue Typing Laboratory of the Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark 5 Department of Rheumatology, Gentofte University Hospital, Copenhagen, Denmark ...

To present the pioneering concept, Peer and his team encoded the anti-inflammatory protein interleukin-10 into mRNA and ...

Here we investigated the role of interleukin (IL)-17A-induced HSP47 expression in intestinal fibrosis in CD ... which could contribute to intestinal fibrosis in CD. The aims of the present study were ...

2 National Institute for Health Research Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London, UK Objective The functional role of interleukin-22 ...

Before Pippa Tyrrell led the overhaul of Manchester’s stroke services, patients were admitted to general medical and geriatric wards in their local hospital and had limited access to emergency brain ...