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Science丨细胞RNA与MAVS相互作用促进抗病毒信号传导
当前哨蛋白,如 RIG-I样受体(RIG-I–like receptor,简称RLR)家族中的前哨蛋白,感知病毒RNA基序,诱导I型和III型干扰素(interferons,简称IFN)、促炎细胞因子和细胞防御基因,从而建立抗病毒状态时,就会启动针对RNA病毒的先天免疫 【1, 2】。尽管强大的抗病毒 ...
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