Taken together, epigenetic changes that alter chromatin structure have surpassed the proof of principle stage and now offer new dimensions for cancer diagnosis and therapy. With expanding use of ...

Background: Obesity is an emerging health problem worldwide as it is associated with increased risk of cardiovascular, metabolic, mental disorders, and cancer. Therapeutic weight management remains ...

1 University of Manchester, Centre for Epidemiology Versus Arthritis, Manchester, United Kingdom 2 Manchester University NHS Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, ...

Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune ...