Why Do I Have IgA Nephropathy? Even though it’s one of the most common kidney diseases, doctors don’t know why it happens. It most often appears in adolescence or younger adulthood.

Immunoglobulin A (IgA) nephropathy, also called Berger’s disease, is an autoimmune disease that affects your kidneys. IgA is an antibody. Antibodies are proteins made by your immune system.

An increase in the proportion of serum IgA molecules that are poorly O-galactosylated has been one of the most consistent findings in studies of IgAN over the past decade. 1,2 Perhaps more ...

However, about 30% to 40% of those with IgA nephropathy develop kidney failure 20 to 30 years after symptom onset. Early ...

Opens in a new tab or window The FDA granted accelerated approval to atrasentan (Vanrafia) for the reduction of proteinuria in adults with primary immunoglobulin A (IgA) nephropathy, maker ...

Atrasentan is approved for proteinuria reduction in primary IgA nephropathy, a condition risking kidney failure. The phase 3 ALIGN study showed atrasentan reduced proteinuria by 36.1% compared to ...