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USP9X:卵巢癌治疗新靶点 —— 调控关键通路逆转化疗耐药
为解决卵巢癌化疗耐药难题,研究人员开展了关于 USP9X 在卵巢癌中作用的研究。结果发现,USP9X 整合 TGF-β 和缺氧信号,维持癌细胞干性促进化疗耐药,抑制 USP9X 可增强化疗敏感性。这为卵巢癌治疗提供了新策略 1229 。
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