Hydrocodone bitartrate ... buprenorphine); may reduce effects and precipitate withdrawal symptoms. Potentiated by CYP3A4 inhibitors (eg, macrolides, azole antifungals, protease inhibitors).

Hydrocodone-acetaminophen (the generic version ... Taking either of these during pregnancy may cause life-threatening withdrawal symptoms in the newborn. This is called neonatal opioid withdrawal ...

Hydrocodone bitartrate 5mg ... Pregnancy; potential neonatal opioid withdrawal syndrome during prolonged use. Nursing mothers: not recommended. Increased risk of respiratory depression, sedation ...

Early opioid withdrawal symptoms include restlessness, anxiety, insomnia, and muscle aches. Late opioid withdrawal symptoms are more serious and involve vomiting, diarrhea, and a rapid pulse.