The SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) that in turn co-ordinates the expression of clock-controlled genes (CCGs) directing circadian programmes of ...

Grey denotes the dark period of the cycle. Figure 3. Effect of ZFHX3-KO on SCN transcriptome. (A) Mean-difference plot (MD-plot) showing downregulated (red) and upregu-lated (blue) gene expression ...

A. Simeone, D. Acampora, V. Nigro, A. Faiella, M. D'Esposito, A. Stornainolo, et al., "Differential regulation by retinoic acid of the homeobox genes of the four HOX loci in human embryonal carcinoma ...

M.P. Kamps, C. Murre, X.-h. Sun, D. Baltimore, "A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in Pre-B ALL," Cell, 60:547- 55, 1990. Mark Kamps ...

The WUSCHEL-related homeobox (WOX) gene family plays a crucial role in various aspects of plant development, including embryogenesis, organ formation, and responses to environmental stresses.

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

The Connexin 40 -enhanced green fluorescent protein (Cx40eGFP), Cx40- Cre recombinase fused to a tamoxifen-inducible estrogen receptor (Cx40-CreERT2), NK2 Homeobox 5 gene with a Cre recombinase ...

Scientists led by a team at Columbia University have trained a model to predict how the genes inside a cell will drive its behavior, which could be a powerful tool with the potential to broaden ...

Types 1 and 2 diabetes appear to be caused by an interplay of genetic, environmental, and lifestyle factors. Over the years, researchers have found an array of specific genes that are linked to ...