The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is responsible for the epigenetic regulation of gene expression through specific methylation of lysine79 residue ...

In this review, we will discuss one such target, the histone lysine specific demethylase 1 (LSD1). Prior to the discovery of LSD1, histone methylation was considered a static process. Unlike the ...

Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation ...

Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States ...

Histone Demethylases: Enzymes that remove methyl groups from histones ... H3K27me3: A specific trimethylation mark on histone H3 at lysine 27, often associated with gene repression.

Department of Chemistry, King’s College London, Britannia House, 7 Trinity Street, London SE1 1DB, U.K.

The field encapsulates modifications made directly to DNA and post-translational modification of histones. In this study, we will explore DNA methylation and histone acetylation, in the context of ECM ...

Drugs targeting amyloid plaques have failed to show efficacy in clinical trials. A new approach is needed to tackle AD ...

Dunn, recently carried out a study exploring how DNA methylation, an epigenetic modification that entails the addition of a methyl group to the DNA, contributes to the well-documented relationship ...