The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is responsible for the epigenetic regulation of gene expression through specific methylation of lysine79 residue ...

In this review, we will discuss one such target, the histone lysine specific demethylase 1 (LSD1). Prior to the discovery of LSD1, histone methylation was considered a static process. Unlike the ...

The most popular of these treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation can reactivate genes that have been silenced. Two examples of these ...

The field encapsulates modifications made directly to DNA and post-translational modification of histones. In this study, we will explore DNA methylation and histone acetylation, in the context of ECM ...