Furthermore, we demonstrated that LPS upregulated the expression of LINC00152 by introducing histone lactylation on its promoter and decreasing the binding efficiency of the repressor, YY1, to it. Our ...

This study explores the mechanisms of epilepsy-associated neuronal death mediated by lactate metabolism and protein lactylation. This study also examines the potential for histone deacetylase ...

Background: Lactylation plays an essential role in pancreatic cancer, but the precise role of lactylated histone in the diagnosis and prognosis of pancreatic cancer remains to be further clarified.

In a groundbreaking study led by Dr. Ying Chen and her team from Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, researchers have uncovered a novel mechanism behind endothelial ...

肿瘤细胞的有氧糖酵解（Warburg 效应）与多种恶性行为相关，且乳酸衍生的组蛋白赖氨酸乳酸化是一种新型表观遗传修饰，可直接增加染色质内的基因转录。神经元前体细胞表达发育下调蛋白 4（NEDD4）作为 HECT 结构域 E3 连接酶家族的重要成员，在肿瘤细胞的多种过程中发挥关键作用，但 NEDD4 是否参与奥沙利铂和 5 - 氟尿嘧啶耐药的 HCC 发展尚不明确。

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

近日，由芝加哥大学吴小阳/Huang Jun领衔的研究团队，在著名期刊 Cell Reports Medicine 上发表一篇重要研究论文 [8]，创新性发明了一种乳酸特异性给药系统，专门针对爱产乳酸的肿瘤。采用这个给药系统之后，可以大幅提高 抗癌药 ...