Many drugs from different chemical classes and therapeutic areas have been shown to inhibit currents mediated via the hERG-coded ion channel, which is strongly correlated to a risk of inducing TdP.

As such, hERG channels are the main target for proarrhythmogenic screening ... CENTRE FOR CELL BIOLOGY, DEVELOPMENT, AND DISEASE (C2D2) 3RD ANUUAL MEETING, MAY 2019, BC CANCER AGENCY. TSE NING CHEUNG ...

Expert Rev Clin Pharmacol. 2010;3(3):321-329. Despite a propensity to block hERG channel function, as determined by electrophysiology, for a limited number of compounds no cardiac arrhythmias have ...