Figure 1. During sepsis, liver macrophages (Kupffer cells) in hepatic sinusoids synthesize large amounts of inflammatory cytokines (TNF-α, IL-6, IL-1β) through the TLR4-MyD88/NF-κB pathway. Moreover, ...

Massive infiltration of liver sinusoids by lymphoma cells (Figure 1) and NRH (Figures 1 and 2) was confirmed. The patient was therefore diagnosed with primary splenic lymphoma and hepatic ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

The liver is a multifunctional organ that plays crucial roles in numerous physiological processes, such as production of bile and proteins for blood plasma, regulation of blood levels of amino acids, ...

19 described many minute communications between the portal and hepatic veins in cirrhotic livers. These anastomoses were considered to be remnants of previous sinusoids that had dilated and whose ...

Liver cancer is uncommon in the United States, but it is common worldwide due to risk factors such as chronic hepatitis B and C infections and exposure to aflatoxin (toxins produced by a certain ...

Systemic levels act on many organs and tissues including bone and endothelium, but little is known about its hepatic functions in health and disease. Design Levels of BMP-9 and its receptors were ...

When we hear the word "hepatitis," we tend to associate it with cirrhosis and other disorders affecting the liver. But it's not always the case. As with other persistent, chronic infections, hepatitis ...