Earlier attempts using ovarian organoids have failed to produce a viable bi-paternal mouse due to abnormalities in the ...

Researchers in China have achieved what many believed couldn't be done: they've created viable, healthy mice using genetic ...

A research group led by Wei Li at the Chinese Academy of Sciences has created mice born from two male parents and capable of ...

A mouse with no biological mother has survived to adulthood in China – a major scientific achievement that's been years in ...

A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse—a mouse ...

Researchers created the first bi-paternal mouse by modifying imprinting genes, advancing reproductive science but facing ...

孤雄小鼠的研究，为哺乳动物印记基因的形成及其在单性生殖障碍中的作用，提供了更合理的解释。修复单个印记基因异常就能成功产生孤雌小鼠，但孤雄小鼠实验表明，印记基因的演化目标并非直接阻止单性生殖。实际上，印记基因和单性生殖的关系更多是间接效应：当体内有两套 ...

By using genetic material from two male mice, researchers successfully created pups that survived to adulthood, offering ...

孤雄小鼠的研究，为哺乳动物印记基因的形成及其在单性生殖障碍中的作用，提供了更合理的解释。修复单个印记基因异常就能成功产生孤雌小鼠，但孤雄小鼠实验表明，印记基因的演化目标并非直接阻止单性生殖。实际上，印记基因和单性生殖的关系更多是间接效应：当体内有两套父本 DNA 时，胚胎往往过度生长，而这种过度生长在生物学上不可持续，最终影响存活。虽然这些异常的单独效应不致命，但修复它们却能产生可存活的个体。

Segmental duplication or low-copy repeat. A segment of DNA >1 kb in size that occurs in two or more copies per haploid genome, with the different copies sharing >90% sequence identity. They are ...

Cell reprogramming is the process of reverting mature, specialised cells into induced pluripotent stem cells. Reprogramming also refers to the erasure and re-establishment of epigenetic marks ...

科学的进步往往源于对未知大胆探索，而一些看似遥不可及的技术突破，实际上已经悄然走在了时代的前沿。近年来，生殖医学和基因工程的结合不断推动着医学的边界，尤其是在哺乳动物克隆和干细胞技术的应用上。最近，一项突破性的研究显示，通过直接修改哺乳动物中的印记基 ...