All available evidence indicates that PML-NB proteins associate with HSV-1 and HCMV genomes at the very beginning of both lytic and quiescent infections, and implies that this association is also ...

There are many similarities but also important differences in how HSV-1 and HCMV initiate lytic gene expression, the classes of viral genes silenced by PML-NB proteins and the mechanisms employed ...

We developed “Circrnas in Host And viRuses anaLysis pIpEline” (CHARLIE) to facilitate viral profiling. This method identified thousands of back-splicing variants, including circRNA common to lytic and ...

The SV Enhancement package adds $4995 to the bill. For the first time, HSV is offering four different engine tunes for the HSV range, and a new SV Enhancement package which is available for the ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

Compared to women, men are half as likely to get HSV-2 due to vulnerabilities in the female genital tract. Simply put, vaginas have larger areas of mucosal membranes than penises. These ...

Both oral herpes and genitals herpes are caused by types of the herpes simplex virus (HSV). The virus is passed when you come in contact with a herpes sore or its fluids. The virus can also be passed ...

Whilst the ultimate outcome of the lytic cycle is production of new phage progeny and death of the host bacterial cell, this is a multistep process involving precise coordination of gene transcription ...

They achieve this by switching between two phases: the lytic phase, where the virus actively replicates ... Among the eight known human herpesviruses, v-miRNAs have been identified in Herpes Simplex ...

Figure 2: FIAU accumulation rates (K i FIAU) demonstrate viral TK activity in HCT8 cells after infection with each of 3 HSV-1 recombinants. Figure 3: Transaxial PET images of viral-treated human ...

Division of Evolution, Infection & Genomic Sciences, University of Manchester, Manchester M13 9PL, U.K. Division of Evolution, Infection & Genomic Sciences ...