While these observations provide a baseline for the potential use of a CRISPR-based gene editing strategy for the elimination of HIV-1 and a cure of AIDS, evaluation of potential off-target effects ...

Strebel K, Klimkait T, Martin MA . A novel gene of HIV-1, vpu, and its 16-kilodalton product. Science 1988; 241:1221–23.

While HIV-1 infection of target cells with cell-free viral particles has been largely documented, intercellular transmission through direct cell-to-cell contact may be a predominant mode of ...

1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical ...

Sep. 25, 2024 — Almost everyone knows about HIV. Fewer people know about its relative, HTLV-1. However, HTLV-1 can cause serious illnesses, including cancer. To develop ways to combat this virus ...

Using a new mathematical model to analyze a detailed set of viral load data collected from five infected patients after the administration of a potent inhibitor of ...

Eight patients completed the full duration of the study with four of them showing a reduction in total HIV DNA ranging from 2% to 85%, and four patients experienced an increase of viral load ...

Physicians and their patients report that engagement in an HIV-based community rivals drug effectiveness in the ongoing efforts to curtail an epidemic. Confronting the HIV Epidemic: There's an App ...

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Jan. 30, 2025 — A research group has developed new advanced light-controlled tools that enable precise control of proteins in real time in living cells. This groundbreaking research opens doors ...

Neurons that secrete the neuropeptide orexin help mice decide between exercise and snacking.