Curing HIV will be harder than curing cancer. But new research is promising.HIV is "like a time bomb," said James Riley, a microbiologist at University of Pennsylvania, US. Scott Kitchen, an expert in ...

HIV-1 Tat has been the vanguard of Pol II transcription elongation control for more than two decades 3.Nevertheless, its mechanism of action has ceased to be recognized as a viral peculiarity only ...

Pseudoscience has recently re-emerged in the U.S. While much of it concerns vaccines, an "oldie" is again making the rounds: HIV is neither the cause nor the sole cause of AIDS. This nonsense has been ...

After removing the nucleos(t)ide analog reverse-transcriptase inhibitor monophosphate, the mode of DNA polymerization becomes active again (bottom). The P site and N site of HIV-1 reverse ...

On left, the HIV virus binds to CD4 T cell CD4 receptor, which will allow the ... [+] co-receptor CCR5 to melt and release the viral RNA into the cytoplasm. After reverse transcription ...

This suggests that the dynamics of proviral transcription are influenced by host factors and may play a role in the persistence of HIV-1 in the body. Immunotherapy approaches, such as the use of ...

target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease. Historically, most people started HIV treatment with two drugs from the NRTI class ...

It is an ester-derived prodrug that is converted in vivo by serum and tissue esterases to tenofovir, an acyclic nucleoside phosphonate (nucleotide) that inhibits HIV reverse transcriptase.

researchers have been investigating strategies to activate HIV transcription in latently infected cells, and to eliminate selectively those cells that harbor the virus. Dean Hamer of the National ...

Because of these differences in the silencing machinery we have been able to identify selective activators of HIV transcription in the two different cell types. Extending this work we plan to develop ...

The major focus of our research is on the HIV Tat protein, which is essential for HIV transcription, and on two cellular factors, cyclin T1 and Cdk9, which are necessary for Tat function. We are ...