HIV-1 Tat has been the vanguard of Pol II transcription elongation control for more than two decades 3.Nevertheless, its mechanism of action has ceased to be recognized as a viral peculiarity only ...

Curing HIV will be harder than curing cancer. But new research is promising.HIV is "like a time bomb," said James Riley, a microbiologist at University of Pennsylvania, US. Scott Kitchen, an expert in ...

Sequence variations in human immunodeficiency virus (HIV)-1 reverse transcriptase (RT) and protease, the molecular targets of anti-retroviral drug therapy, are prime examples of genes in which ...

After removing the nucleos(t)ide analog reverse-transcriptase inhibitor monophosphate, the mode of DNA polymerization becomes active again (bottom). The P site and N site of HIV-1 reverse ...

The four main classes, which most people are treated with, target one of three viral proteins which control HIV’s lifecycle: reverse transcriptase, integrase and protease. Historically, most people ...

The major focus of our research is on the HIV Tat protein, which is essential for HIV transcription, and on two cellular factors, cyclin T1 and Cdk9, which are necessary for Tat function. We are ...

Because of these differences in the silencing machinery we have been able to identify selective activators of HIV transcription in the two different cell types. Extending this work we plan to develop ...

It is an ester-derived prodrug that is converted in vivo by serum and tissue esterases to tenofovir, an acyclic nucleoside phosphonate (nucleotide) that inhibits HIV reverse transcriptase.

16). To eliminate the hidden HIV reservoir, researchers have been investigating strategies to activate HIV transcription in latently infected cells, and to eliminate selectively those cells that ...