The application of HDAC inhibitors for the treatment of various CNS disorders has emerged in recent years. Chromatin remodelling and transcriptional modulation may underlie the efficacy of HDAC ...

The Celgene-Acetylon deal is back from the dead, seven months after the initial option agreement lapsed. Celgene is not all-in, however, which means Acetylon's pipeline will now be split into two.

22 Future research should explore the relationship between kynurenine metabolism and HDAC inhibition, considering novel inhibitors that could enhance treatment efficacy. Investigating NAD+ metabolism ...

The HDAC inhibitor was given an accelerated approval ... focusing mainly on checkpoint inhibitors that have seen new uses added to their labels at breakneck speed since being launched onto the ...

Eight months after announcing the $18.5 million first tranche of its series A, Augustine Therapeutics has closed the oversubscribed round at $85 million and is now ready to begin clinical development ...

with or without factor VIII or IX inhibitors (neutralizing antibodies). "Today's approval of Qfitlia is significant for patients with hemophilia because it can be administered less frequently than ...