Researchers from the University College Cork have described the neuroprotective effect of TMP-269, a class-IIa-specific histone deacetylase (HDAC) inhibitor in preclinical models of PD. Pan-inhibitors ...

Drugs aimed at histone modifications are called histone deacetylase (HDAC) inhibitors. HDACs are enzymes that remove the acetyl groups from DNA, which condenses chromatin and stops transcription.

Monoamine Oxidase Inhibitors (MAOi); tranylcypromine and pargyline, tranylcypromine derivative irreversible LSD1 inhibitors; GSK2879552, ORY-1001, ORY-2002, IMG7289, INCB059872, combination LSD1 and ...

Cancer biotech Viracta Therapeutics has closed its doors, laying off all employees and winding down operations.

The company is still seeking strategic options for its development programs, including nana-val, which it was testing in EBV-positive refractory lymphoma.

This review will provide insight into the overview structure of LSD1, summarize its action mechanisms in BC, describe the therapeutic potential of LSD1 inhibitors in BC, and prospect the current ...

Correspondence to Dr Razia Zakarya, Respiratory Cell and Molecular Biology, Woolcock Institute of Medical Research, Glebe, NSW 2037, Australia; Razia.Zakarya{at}sydney.edu.au Rationale In COPD, small ...

Navega Therapeutics Inc. has received a $4 million Translational Science grant from the California Institute for Regenerative Medicine (CIRM) to support its work addressing neuropathic pain. The grant ...

retriever generates disease-specific transcriptional drug response signatures by merging transcriptional signatures over time, concentration, and cell-type. These signatures can then be matched to ...

After hours: January 29 at 5:37:10 p.m. EST Loading Chart for SHPH ...

In this capacity menin is a regulator of expression of the cyclin-dependent-kinase inhibitors p18INK4C and p27Kip1; furthermore, menin serves as a co-activator of estrogen receptor mediated ...