A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression. A national study ...

Drugs aimed at histone modifications are called histone deacetylase (HDAC) inhibitors. HDACs are enzymes that remove the acetyl groups from DNA, which condenses chromatin and stops transcription.

Cancer biotech Viracta Therapeutics has closed its doors, laying off all employees and winding down operations.

A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression. Houston Methodist and ...

There were more grade 3/4 drug-related adverse events, however, coming in at 18.9% in the combination arm compared to 9.7% with Opdivo, and discontinuation rates were 14.6% and 6.7%, respectively.

Monoamine Oxidase Inhibitors (MAOi); tranylcypromine and pargyline, tranylcypromine derivative irreversible LSD1 inhibitors; GSK2879552, ORY-1001, ORY-2002, IMG7289, INCB059872, combination LSD1 and ...

Interaction explained:Angioedema is a side effect of Rapamune and ACE inhibitors. When these drugs are taken together, the risk of developing angioedema may be increased. Examples of ACE inhibitor ...

It is also specifically amplified in breast cancer and contributes to BC tumorigenesis and drug resistance via both demethylase and non-demethylase manners. This review will provide insight into the ...

A national study seeking more effective treatment for deadly metaplastic breast cancer has identified two inhibitor drugs with the potential to interrupt disease progression. Houston Methodist and ...

retriever generates disease-specific transcriptional drug response signatures by merging transcriptional signatures over time, concentration, and cell-type. These signatures can then be matched to ...