Peptide-based vaccines offer excellent alternatives to traditional vaccination approaches because of the ease with which chemical modifications can be introduced. Peptide-based vaccines can be ...

They may also be signalling molecules that act through interaction with specific receptors, as in peptide hormones and cytokines. Recently developed chemical and enzymatic methods to cyclize ...

Intranasal vaccination is a desired route for protection against influenza viruses by mucosal and systemic immunity. However, the nasal mucosa impedes the intranasal delivery of vaccines. Here, we ...

The impacts of highly pathogenic enveloped viruses, such as SARS-CoV-2, have turned scientific inquiry toward the fusion mechanisms responsible for viral pathogenesis and to seek cost-effective and ...

Many peptide medications like glucagon-like peptide-1 (GLP-1) receptor agonists were initially developed to treat type 2 diabetes. One unexpected side effect of these drugs is weight loss.

(D) Bar graphs showing the percentage cleavage efficiency for each trimming step for mutant enzyme compared to WT enzyme. Cleavage events where the precursor Aβ peptide level was zero (i.e., no ...

Each chain is initially synthesized as a precursor polypeptide, which is then cleaved into two parts: HA1 (328 amino acids) and HA2 (221 amino acids), connected by disulfide bonds. 5 In this study ...