Excessive glutamate release has been linked to stress and many neurodegenerative diseases. Evidence indicates abnormalities of glutamatergic neurotransmission or glutamatergic dysfunction as playing ...

Glutamatergic Transmission: The process by which the neurotransmitter glutamate is released and acts on receptors in the brain, playing a key role in synaptic transmission and plasticity.

With regard to understanding the disease process in AD, it is of considerable interest to consider the temporal relationship between the loss of cholinergic and glutamatergic neurons. Biochemical ...

Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and ...

Among the many compounds under investigation, NMDA and metabotropic glutamate receptor antagonists and negative allosteric modulators appear particularly promising due to their ability to inhibit ...

Although compounds with a combined cholinergic–glutamatergic action have been trialed, none has yet been successful in the later stages of development (Table 4). Consequently, combination ...

In preliminary studies, we discovered that selected typical and atypical antipsychotic drugs interacted with virtually every biogenic amine receptor tested, in confirmation of many prior studies ...

A study published in Science Signaling on the neural circuitry mediating addiction has made significant strides, particularly in understanding the intricat | Neuroscience ...

Neuroscientists have identified that the receptor IL-1R1 plays a critical ... reveal that chronic IL-1 signaling in glutamatergic neurons influences cognitive and social-avoidance behaviors ...

In addition, we did not monitor levels of 5HT1a receptors, which are also known to regulate anxiety-related behaviors (Ishikawa and Shiga, 2017), and did not perform a detailed monitoring of food ...

It has yet to be revealed where or how IL-1R1 (Interleukin-1 Receptor Type 1 ... reveal that chronic IL-1 signaling in glutamatergic neurons influences cognitive and social-avoidance behaviors ...