Ketamine may work in other ways in the brain, too. Some nerve cells in the brain involved in mood use a chemical called glutamate to communicate with each other. The nerve cells need glutamate ...

The findings point the way to treatment options targeting group 1 metabotropic glutamate receptors. This study is a major step toward the ultimate goal of treating fragile X syndrome (FXS), an ...

Glutamate stimulates the brain ... One study shows that those suffering from depression, epilepsy, post-traumatic stress disorder (PTSD), and chronic pain—all medical conditions that involve ...

Most of these neurons use glutamate (a neurotransmitter for signaling), while some use serotonin (important for mood). They found that these IL-1R1-positive neurons are involved in circuits that ...

Our work primarily focuses on understanding the mechanisms underlying chronic stress, trauma, depression, and suicidality. We place particular emphasis on the glutamatergic system including ...