Patients with relapsed ovarian cancer who had germline or somatic BRCA mutations saw greater OS with olaparib, according to ...

Background: Homologous recombination repair deficiency is associated with higher risk and poorer prognosis for prostate cancer. However, the landscapes of somatic and germline mutations in these genes ...

Somatic or acquired mutations are by far the most common type of mutation associated with cancer. Related: Hereditary (Germline) vs. Acquired (Somatic) Gene Mutations How the TP53 Gene May Be ...

People with Li-Fraumeni syndrome often develop cancer as children or young adults, and the germline mutation is associated with a high lifetime risk of cancers, such as breast cancer, bone cancer, ...

Ryan J. Corbett^, Rebecca Kaufman^, Shelly W. McQuaid, Zalman Vaksman, Saksham Phul, Miguel A. Brown, Jennifer L. Mason, Sebastian M. Waszak, Bo Zhang, Chuwei Zhong ...

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada Results: A novel germline CDH1 truncating mutation in the extracellular portion of ...

Phenotypic and genotypic characterization of an inherited CEBPA germline mutation in a case of pediatric acute myeloid leukemia. (A) The heterozygous germline CEBPA (p.Val119Alafs*42) variant in ...

Summary: A new study has uncovered a direct link between somatic mutations and epigenetic modifications, challenging established views on aging. Researchers found that random genetic mutations drive ...