Mount Sinai Icahn scientists took detailed pictures of how drugs can bind to the TAAR1 receptor using CryoEM. They also discovered that an antipsychotic drug, asenapine, unexpectedly activates ...

The receptor molecule (stringlike structure in different colors) maneuvers a strand of DNA (purple). The DNA binding domain is red and pink, the ligand binding domain is green and teal and the ...

In addition to the 'traditional' actions of steroid-hormone–receptor complexes ... within the same SHBG steroid-binding site 56. Again, here is a hurdle for drug discovery.

New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D.