Mount Sinai Icahn scientists took detailed pictures of how drugs can bind to the TAAR1 receptor using CryoEM. They also discovered that an antipsychotic drug, asenapine, unexpectedly activates ...

"The advantage of this is that extracellular regions are very different from each other, so you can target them with a drug that doesn't bind to other receptors and cause unwanted side effects." ...

New research sheds light on how ketamine affects the brain by targeting a specific NMDA receptor subtype, GluN1-2B-2D.

In a new study, Cold Spring Harbor Laboratory Professor Hiro Furukawa and postdoc Hyunook Kang prove the existence of a mysterious brain receptor known as GluN1-2B-2D. They also show several ways the ...