Researchers can experimentally interrogate the function of one or more genes using knockout or knockdown tools. Although both approaches ultimately interfere with gene function, knockout and knockdown ...

Transform the verified clones into the cell lines of interest to test their ability to knock down gene expression. The vector(s) may be transiently transfected into any commonly used cell line ...

1 Scientists have harnessed RNAi in the laboratory to selectively silence target gene expression, a technique known as gene knockdown. 8 By delivering dsRNA that are complementary to a target gene’s ...

The Phase Ib trial is set to test a gene therapy designed to target a rare disorder that causes muscle and respiratory failure.