thereby reversing lactylation modifications. This process can lead to alterations in chromatin structure and gene expression levels, potentially activating or silencing genes. Histone deacetylases ...

Histone deacetylases may affect protein lactylation by regulating the transcriptional activity of HIF-1 ... Elevated intracellular lactate levels not only promote the translocation of HIF-1α from the ...

In a groundbreaking study led by Dr. Ying Chen and her team from Ruijin Hospital, Shanghai Jiao Tong University School of ...

Background: Lactylation plays an essential role in pancreatic cancer, but the precise role of lactylated histone in the diagnosis and prognosis of pancreatic ... Moreover, H3K18la protein expression ...

Long considered simply a product of muscle metabolism and a source of energy for neurons, lactate is now recognized as an epigenetic regulator, activating gene transcription ... AD mutations, APP ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

近日，由芝加哥大学吴小阳/Huang Jun领衔的研究团队，在著名期刊 Cell Reports Medicine 上发表一篇重要研究论文 [8]，创新性发明了一种乳酸特异性给药系统，专门针对爱产乳酸的肿瘤。采用这个给药系统之后，可以大幅提高 抗癌药 ...

This complex process, known as gene expression, determines which proteins we make and whether we make them in the correct amounts, crucial work given that proteins play a role in virtually every a ...