During the elongation cycle of protein biosynthesis on the ribosome ... Domain I comprises two subdomains, the GTP-binding G domain and an insertion, the G' domain. Recently, using cryo-electron ...

This important study demonstrates the potential of synthetic gene circuits to detect and target aberrant RAS activity in cancer cell lines. The circuit design is novel and the evidence supporting the ...

Institute of Pharmaceutical Analysis, Key Laboratory of Chemical Biology (MOE), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China ...

Get Instant Summarized Text (Gist) A simplified method called ProteinReDiff enhances ligand-binding protein redesign using artificial intelligence. It leverages representation learning from ...

The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

The ability to alter protein binding can create tailored therapeutics with reduced side effects, sensitive diagnostic tools, targeted drug delivery and sustainable ...

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

Every cell in the body normally has its fixed place as part of a tissue structure. Except for a few cell types, such as blood ...

Please provide your email address to receive an email when new articles are posted on . Presence of a protein-binding biomarker in a small cohort of adults with depression may be an indicator that ...