and calcium sensing receptor family of GPCRs to dimerize. A number of studies have explored the effect of agonists on the level of receptor dimers and found that, in some cases, they stabilize and ...

cAMP, calcium and IP3 are the second messengers commonly assessed to follow GPCR activation. Drugs targeting GPCRs account for the majority of the best-selling drugs and about 40% of all ...

In completed 28-day preclinical toxicology studies, SEP-786 was generally well-tolerated, without predicted risk of bilirubin elevation. In response to these Phase 1 events, Septerna has initiated non ...

Reproducing GPCR activation outside a cellular environment ... PTH is essential for calcium and phosphate homeostasis. It works by activating PTH1R in bone and kidney cells, which then releases ...

Current treatments mainly involve calcium and vitamin D supplementation ... which underscores the power of our Native Complex ...

Various assays are supported by the FLIPR Penta System, including GPCR assays that use FLIPR Calcium Assay Kits and membrane potential tests that use the FLIPR Membrane Potential Assay Kit ...

We identified GPR30 as a bicarbonate-sensing GPCR and then shifted our focus to ... from the culture medium lowered GPR30 activation (calcium responses) in GPR30-overexpressing MCF-7 and HEK ...