In this diagram of G-protein-coupled receptor activation ... These activated subunits can act on ion channels in the cell membrane, as well as cellular enzymes and second messenger molecules ...
The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...
Membrane receptors fall into three major classes: G-protein-coupled receptors, ion channel receptors, and enzyme-linked receptors. The names of these receptor classes refer to the mechanism by ...
The variable topology of the G protein-coupled receptor (GPCR) autoproteolysis inducing (GAIN) domain. Credit: Nature Communications (2025). DOI: 10.1038/s41467-024-55466-6 ...
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