While this has been well established, the dimerization of G-protein coupled receptors (GPCRs) (that represents ∼1% of the genes present in a mammalian genome) has not been well documented until ...

G-protein coupled receptors regulate hormone secretions in the pancreas. Learn how the complex signaling features of these receptors are illuminating diabetes research. Diabetes results from ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...

The variable topology of the G protein-coupled receptor (GPCR) autoproteolysis inducing (GAIN) domain. Credit: Nature Communications (2025). DOI: 10.1038/s41467-024-55466-6 ...