Intercellular adhesion can be mediated by adherens junctions, tight junctions and desmosomes, whereas cells can interact with extracellular matrix molecules through focal adhesions. Differences in ...

On binding to ECM molecules, integrins are thought to undergo a conformational change, which allows the intracellular domain of their β-subunit to interact with focal-adhesion proteins ...

Researchers at the University of California San Diego have uncovered a key mechanism underlying the treatment resistance of melanoma with the BRAF V600E mutation through pathways involved in focal ...

an Australian pharmaceutical company specializing in Focal Adhesion Kinase inhibitors for cancer and fibrosis, has announced ...