Megakaryocytes form a three-dimensional (3D) cage composed of laminin and collagen IV connected to the basement membrane surrounding them. This microarchitecture stabilizes megakaryocytes within their ...

Discover the power of hydrogel: researchers at Penn State mimic tissue behaviors using special hydrogels for potential ...

Peptides have emerged as a fascinating class of biomolecules with multifaceted roles across biological systems. Vesugen, a ...

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of extracellular matrix (ECM), or "scar," that follows chronic but not self-limited liver disease. The ECM ...

ECM can directly influence the function of ... liver injury include alterations in both cellular responses and extracellular matrix composition. Stellate cell activation leads to accumulation ...

The 3D cell culture industry is poised for substantial growth from 2025 to 2035, driven by advancements in biotechnology and ...

Scientists are urgently seeking fluid biomarkers for frontotemporal dementia, the most common dementing illness among 40- and ...

Penn State researchers have created LivGels, a self-healing hydrogel that mimics extracellular matrix (ECM) properties, ...

The University of Oulu is at the forefront of developing cutting-edge biosensor technology that could revolutionize the early ...

A biomaterial that can mimic certain behaviors within biological tissues could advance regenerative medicine, disease modeling, soft robotics and more, according to researchers.

然而，目前用于荧光标记细胞外生物分子的方法在活体组织应用中存在诸多挑战。基于蛋白质的亲和试剂（如抗体和凝集素），由于空间扩散性差，难以在组织中有效分布；病毒递送标记的高分子量 ECM 成分，受到病毒包装限制；内源性遗传标签则需要大量优化，以避免干扰 ECM 的正常组装，而这对于生物体的发育至关重要。此外，现有方法难以实现多重标记，无法全面展示 ECM ...

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