Histopathologic examination shows numerous granulomas of epithelioid histiocytes surrounded by a dense infiltrate of lymphocytes (hematoxylin and eosin staining, x5 original magnification).

Etiology: The cause of granuloma annulare is unknown. Granuloma annulare can occur at any age, but is seen predominantly in children and young adults. It occurs more frequently in females than males.