Transition-state theory has provided the theoretical framework to explain the enormous rate accelerations of chemical reactions by enzymes. Given that proteins display large ensembles of conformations ...
Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K. Protein kinase R-like ...
Enzymes are generally proteins but also include catalytic DNA and catalytic RNA. As effective biological catalysts, enzymes work by lowering a reaction’s activation energy barrier, thereby ...