EGA is known to block the trafficking from EEA1 + endosomes to LAMP1 + endosome/lysosome without affecting recycling endosome trafficking. EGA did not alter the acidification of endo-lysosomes, ...

During endosome maturation Rab5 is replaced by Rab7 on endosomes that are able to fuse with lysosomes to form endolysosomes. However, whether ESCRT-driven ILV formation and Rab5-to-Rab7 conversion are ...

The product of endosome–autophagosome fusion is known as an amphisome. The completed autophagosome or amphisome fuses with a lysosome, which supplies acid hydrolases. The enzymes in the ...

Salmonellae are globally important Gram-negative bacterial pathogens that infect a range of hosts and cause several diseases, including gastroenteritis and typhoid fever. Orally ingested bacteria ...

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.

Innate immunity is the first defense system against invading pathogens. Toll-like receptors (TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition and induction of ...

APP remains within the endosome, leaving it exposed to BACE1 and thus cranking up production of amyloidogenic Aβ peptides. SORL1 also delivers critical synaptic receptors, such as GLUA1, to the ...

Our goal is to unravel the early events that create the endosome/phagosome, a membrane-bound compartment that is moved by motors either to lysosomes for degradation or back to the cell surface for ...

We aim to comprehend the complex process of lysosome biogenesis in health and disease. Advancing our understanding holds promise for novel treatments of cancer and neurodegenerative diseases. The ...

Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria ...

(A) Meiosis II (MII) oocytes were fixed and co-stained with anti-RAB5 and anti-LAMP1 antibodies. The schematic diagram indicates the location of oocyte chromosomes and metaphase plate in the MII ...