Targeting STAT3 signalling in KLHL21-deficient gastric epithelial cells inhibited gastric metaplasia and tumourigenesis. Label-retention studies indicate that epithelial cells of the stomach are ...

Mechanistic studies revealed that upregulated HLF transcriptionally enhanced interleukin 6 (IL-6) expression and intensified signal transducer and activator of transcription 3 (STAT3) phosphorylation, ...

Figure 1: Sequential events that link tumour-cell stress with activation of antigen-presenting cells. Chaperones. A common response to cell stress, including that induced by chemotherapy ...

Busà Photography / Getty Images Many people believe that being wealthy means having a nice house, a late-model car, and a summer cottage, but the kind of money possessed by the wealthiest 1% of ...

STAT3是一种蛋白质，属于一个对控制转录至关重要的蛋白质大家族——将基因复制到RNA中以构建蛋白质的过程。STAT3对胚胎发育至关重要，也参与炎症过程、免疫系统激活和其他生物过程。 以色列理工学院的研究人员发现，在健康状态下（没有病毒感染），NORAD和 ...

Body Dimensions 137.6 x 65.7 x 9.8 mm (5.42 x 2.59 x 0.39 in) ...

To probe the timing of the RNA-seq experiments, we completed RT-qPCR at various time points as shown in Figure 1 – figure supplement 1B. The 4h time point (post-IFNγ) was chosen because robust ...

Learn more› By Caitlin Giddings and Wirecutter Staff When it comes to gifts, many 1-year-olds aren’t picky. In fact, they may be as excited by the packaging as by what’s inside. (Save those ...

We found that FSL-1 inhibited ITGB6 transcription through increasing forkhead box protein O1 (FOXO1) expression and inhibiting signal transducer and activator of transcription 3 (STAT3) activation.

Continuous activation of the IL-6/STAT3 signaling pathway has been detected in liver cancer, lung cancer, breast cancer, ovarian cancer, gastric cancer and other cancers (1–5), and IL-6/STAT3 may be a ...