This study provides important new insights into the contributions of local DNA features to the complex molecular mechanisms and dynamics of copy number variation (CNV) formation during adaptive ...

DNA replication is the biological process by which an exact copy of a deoxyribonucleic acid (DNA) molecule is created and it is the basis for biological inheritance. Each of the two strands of the ...

Second, fork-associated replication proteins ... have other potential target sites that assist in base selection during DNA synthetic processes. For example, drugs that target and inhibit ...

DNA replication is happening continuously throughout ... a medicine could potentially kill the cells by accessing them during the transient state after replication, Ramani explains.

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

[Editors' note: this paper was reviewed by Review Commons.] Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature ...

DNA damage can result in the genetic sequence being misread and copied during cell division—known as DNA replication—and this introduces permanent mutations that can contribute to the ...

Accused of a felony? Refusing to hand your DNA over to a sheriff would be a misdemeanor under legislation moving through Indiana’s Senate. In a Tuesday Corrections and Criminal Law Committee ...

DNA damage can result in the genetic sequence being misread and copied during cell division -- known as DNA replication -- and this introduces permanent mutations that can contribute to the ...