1–3 Researchers need effective methods with high sensitivity and reliability to explore the importance of DNA methylation. The gold standard technology that scientists use to detect DNA methylation is ...

“If you can watch an enzyme move one base pair at a time, that immediately suggests a new way to sequence DNA not based on its chemistry but on its nanomechanics.” The method developed by ...

Changes in DNA methylation patterns occur early during oncogenesis, and each type of cancer has its own methylomic signature. Technological advances in methylation sequencing, or methyl-seq, allow ...

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

Almost all current methods for examining DNA methylation ... the accuracy and sensitivity of dPCR-based DNA methylation analysis. Roche Sequencing & Life Science is part of Roche Diagnostics ...

Unlike traditional methods, this technique does not require de novo DNA synthesis (assembling the molecule's components ... d) Parallel printing via DNMT1-guided catalysis to selectively write ...

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid ...

The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.

The SPRQ chemistry brings three major benefits: 4x lower DNA input, 33% higher sequencing yield and more accurate direct methylation detection. With only 500 ng of DNA needed for a human whole genome, ...

The traditional method of storing data ... of epigenetic modification is DNA methylation, where methyl groups are added to ...

to the native DNA and RNA ... comprehensive epigenetic atlas of methylation data. That’s 50,000 UK Biobank patient samples. As part of a nanopore sequencing run, you get 97–98% methylation.