Although still preliminary, the involvement of cytokine signalling loops in pre-malignant cell-fate decisions, as well as the defects in cytokine-receptor modules seen in later stages of cancer ...

This paradigm shift highlights a key role for the interleukin (IL)-23 cytokine, rather than the previous emphasis on IL-12, as the driving force behind the persistent inflammatory reaction.

But "mRNA really tells you about the ability to produce cytokines, rather than what's actually being produced," says Fred Finkelman of the University of Cincinnati. So many scientists measure cytokine ...

Diseases such as covid-19 and influenza can be fatal due to an overreaction of the body’s immune system called a cytokine storm. Cytokines are small proteins released by many different cells in ...

Aptevo Therapeutics reports strong remission rates in AML patients using mipletamig plus ven/aza, with Cohort 2 enrollment ...

Patients with atopic dermatitis were at greater risk for serious infection after initiating Janus kinase inhibitors vs Th2 cytokine inhibitors.

Siltuximab effectively treated patients who experienced common adverse events after chimeric antigen receptor T-cell therapy, ...

The Flow Cytometry and Cell Separation Facility provides advanced cell sorting and cell analysis techniques including immunofluorescence detection of 18 colors, cell-cycle distribution, apoptosis ...

Defining hypercytokinemia Also called the ‘cytokine storm’, hypercytokinemia is a condition where too many cytokines are released. “They over-trigger the immune system. It’s like a war ...

Several lung conditions, such as acute lung injury, require the targeted delivery of pharmacological agents to the lower lung. However, the administration of complex biologics, such as ...

The clinical consequences of the exercise induced immune changes have not formally been identified, but the exercise effect on lymphocyte dynamics and immune function may be linked to the exercise ...

T helper 17 (Th17) cells generate the pro-inflammatory cytokine interleukin-17 (IL17/IL17A). IL17 has been a target for a variety of therapeutic monoclonal antibodies and inhibitors to treat ...